The associations of parity and maternal age with small-for-gestational-age, preterm, and neonatal and infant mortality: a meta-analysis

N, Kozuki; ACC, Lee; MF, Silveria; A, Sania; JP, Vogel; L, Adair; F, Barros; LE, Caulfield; P, Christian; W, Fawzi; J, Humphrey; L, Huybregts; A, Mongkolchati; R, Ntozini; D, Osrin; D, Roberfroid; J, Tielsch; A, Vaidya; RE, Black; J, Katz
Background Previous studies have reported on adverse neonatal outcomes associated with parity and maternal age. Many of these studies have relied on cross-sectional data, from which drawing causal inference is complex. We explore the associations between parity/maternal age and adverse neonatal outcomes using data from cohort studies conducted in low- and middle-income countries (LMIC). Methods Data from 14 cohort studies were included. Parity (nulliparous, parity 1-2, parity ≥3) and maternal age (ooled aOR: 1.52), neonatal mortality (pooled aOR: 2.07), and infant mortality (pooled aOR: 1.49). Increased odds were also noted for SGA and neonatal mortality for nulliparous/age 18-18 years of age have the highest odds of adverse neonatal outcomes. Family planning has traditionally been the least successful in addressing young age as a risk factor; a renewed focus must be placed on finding effective interventions that delay age at first birth. Higher odds of adverse outcomes are also seen among parity ≥3 / age ≥35 mothers, suggesting that reproductive health interventions need to address the entirety of a woman’s reproductive period.
Research areas:
Year:
2013
Type of Publication:
Article
Journal:
BMC Public Health
Volume:
13
Month:
September
DOI:
10.1186/1471-2458-13-S3-S2
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The Zvitambo Institute for Maternal and Child Health Research is a multidisciplinary Zimbabwean organization that has developed and attracted expertise in various areas of biomedical and applied research and programming in the areas of maternal health, child health and growth, immunology, HIV/AIDS, nutrition, food security and livelihoods, WASH and counseling

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